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Hypoxia-inducible factors in cancer: an overview of major findings from meta-analyses

   
@article{AMJ3793,
	author = {Deli Zou and Tao Han and Han Deng and Xiaodong Shao and Xiaozhong Guo and Xingshun Qi},
	title = {Hypoxia-inducible factors in cancer: an overview of major findings from meta-analyses},
	journal = {AME Medical Journal},
	volume = {2},
	number = {5},
	year = {2017},
	keywords = {},
	abstract = {This paper aims to systematically review the major findings from meta-analyses regarding the impact of hypoxia-inducible factors (HIFs) in various human cancers. A total of 56 eligible meta-analysis papers were identified via the PubMed and EMBASE databases. The associations of HIF-1α gene polymorphism and/or HIF-1α and HIF-2α protein expression with the risk, clinicopathological features, and/or survival were explored in head and neck cancer (n=4), glioma (n=2), oral cancer (n=10), oropharyngeal cancer (n=1), nasopharyngeal cancer (n=1), lung cancer (n=12), breast cancer (n=17), esophageal cancer (n=5), gastric cancer (n=8), colorectal cancer (n=15), pancreatic cancer (n=8), hepatocellular carcinoma (n=5), prostate cancer (n=13), renal cancer (n=13), bladder cancer (n=3), ovarian cancer (n=3), cervical cancer (n=10), endometrial cancer (n=1), and osteosarcoma (n=1). Based on the current evidence, the impact of HIFs should be heterogeneous on various human cancers.},
	issn = {2520-0518},	url = {https://amj.amegroups.org/article/view/3793}
}