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Hepatitis C antiviral therapy: the next generation

   
@article{AMJ3865,
	author = {Alan Hoi Lun Yau and Eric M. Yoshida},
	title = {Hepatitis C antiviral therapy: the next generation},
	journal = {AME Medical Journal},
	volume = {2},
	number = {6},
	year = {2017},
	keywords = {},
	abstract = {In less than a decade, antiviral therapy for chronic hepatitis C (HCV) has undergone dramatic change. The sustained virologic response rate (SVR), defined as HCV RNA undetectability 12 weeks post-therapy, is recognized as being a virologic “cure” and has increased from 40–50%, with peginterferon and ribavirin, to 95–99% with the newest direct acting antiviral agents (DAA) (1). Unlike the non-specific antiviral and immunostimulatory effects of interferon, DAAs specifically target the HCV replicative machinery and include protease inhibitors, NS5a inhibitors and NS5b RNA dependent polymerase inhibitors.},
	issn = {2520-0518},	url = {https://amj.amegroups.org/article/view/3865}
}