TY - JOUR AU - Acton, Richard J. AU - Bell, Christopher G. PY - 2017 TI - Cancer detection and tissue of origin determination with novel annotation and scoring of cell-free methylated DNA JF - AME Medical Journal; Vol 2 (August 2017): Ame Medical Journal Y2 - 2017 KW - N2 - In a recent paper, Guo et al. (1) analysed the methylation of DNA fragments circulating in the blood plasma that are released when cells die. Their analysis used a novel approach to annotate DNA methylation and a methylation status score, which captures both average methylation level and the pattern of co-methylation. They were able to detect lung and colorectal cancers and to predict their tissue of origin. UR - https://amj.amegroups.org/article/view/3978