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Haploid genetic screens identify key regulators of protein phenotypes and signaling transduction

   
@article{AMJ4144,
	author = {Hao Zeng},
	title = {Haploid genetic screens identify key regulators of protein phenotypes and signaling transduction},
	journal = {AME Medical Journal},
	volume = {2},
	number = {11},
	year = {2017},
	keywords = {},
	abstract = {Genome-wide genetic screen has been a powerful system to study the regulation of a variety of signaling pathways, expression and essentiality of genes, and targeted therapy resistance mechanisms in human cells, especially cancer cells (1-5). However, the direct connection between genomic mutations and the regulation of protein states remains elusive. In a recent paper published in Nature, Brockmann and colleagues utilized gene-trap mutagenesis approach coupled with antibody staining for proteins of interest to execute a series of genetic screens in human haploid HAP1 cells, aiming to investigate the direct link between genomic perturbations and specific protein phenotypes (6).},
	issn = {2520-0518},	url = {https://amj.amegroups.org/article/view/4144}
}