Development of acute ischemic stroke in two patients with acute upper gastrointestinal bleeding

Acute ischemic stroke is one of the leading causes of death in the world. Major risk factors include behavior, metabolism, and environment-related factors. To our knowledge, no study has reported the association between acute ischemic stroke and acute upper gastrointestinal bleeding. Herein, we presented two cases of acute upper gastrointestinal bleeding who developed acute ischemic stroke during their hospitalizations. The potential mechanisms for explaining their association were preliminarily discussed.