Targeting autophagy to inhibit wear debris-induced osteolysis

Arthroplasty surgery has become one of the most efficient procedures to restore joint function. However, implant failure due to bone loss is a major complication of joint replacement, with severe consequences both for the individual patient and for health-care systems. Peri-prosthetic loosening without concurrent infection or trauma is called aseptic loosening. It is estimated that up to 20% of all prosthetic implants will induce aseptic osteolysis, generally leading to implant loosening and surgical revision (1).