Cirrhotic patients with venous thromboembolism: how to deal with an unstable balance?

Chronic liver disease may predispose patients to thrombotic events for local risk factors, such as portal hypertension and consequent venous stasis, which can lead to portal vein thrombosis (1). Moreover, the delicate haemostatic balance between reduced production of procoagulant factors and decreased levels of anticoagulants (such as protein C and antithrombin) (2)