Efficacy of pregabalin in patients with sciatica: a randomized, double-blind, placebo controlled trial

Lumbar spinal disorders such as lumbar disc herniation or lumbar spinal stenosis are a cause of sciatica with or without low back pain (LBP). The natural course, typical age, and efficacy of non-surgical treatments for each disorder are different, and the evidence of pharmacological treatment for spinal disorders remains insufficient. Pregabalin is one of the first-line drugs for pharmacotherapy of neuropathic pain (1).