Combined strategies for hepatocellular carcinoma treatment: a new hope

Hepatocellular carcinoma (HCC) is the most common tumor of the liver and the third cause of cancer death worldwide (1). Noteworthy, HCC incidence has increased in the last decades, and mortality rates are still rising among many population groups (2). Despite the efforts in order to detect the disease in its early stages, most tumors are only diagnosed after achieving significant dimensions or local/systemic complications. The Barcelona Clinic Liver Cancer Staging system (BCLC) is one of the most used classifications to stratify patients according to estimated survival, also suggesting the treatment options that should be conducted in each stage based on prior clinical evidences.