Repletion of Nicotinamide adenine dinucleotide restores adult stem cell function and extends lifespan in mice

Aging is a biological process increasingly recognized to be controlled by endogenous signaling and metabolism. It can be modulated by genetic, environmental, and pharmacological perturbations. Importantly, aging not only decreases our quality of life, but also contributes to many fatal diseases. According to the WHO report, the occurrences of many largely incurable pathological conditions, including cancer, diabetes, and neuronal degeneration, are strongly associated with aging (1).