Senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery?

Osteoarthritis (OA) is the most common chronic degenerative disease of the joint for which more than 1/3 of the population after 60 years old have radiographic signs for knee OA (1). OA has pejorative consequences on quality of life and working abilities, leads to a social isolation in elderly and has a significant impact on the public health costs.