Fecal microbiota transplantation: understanding from holistic integrative view

Increasing evidence has shown the role of fecal microbiota transplantation (FMT) in the treatment of dysbiosis related diseases. We need different way for understanding this special therapy concept. The remodeling of microbiota might initiate cascade reactions between bacteria and host. Yin-Yang theory in traditional Chinese medicine could be helpful for us to deeply think the complex mechanism. Importantly, FMT should be managed as a system involving with donor screening, quality control of lab process, safety monitoring, delivering way, frequency, clinical work ow and other aspects. Auto-puri cation of microbiota from healthy stool by GenFMTer in lab with good manufacturing practice level, one-hour protocol of FMT and step-up FMT strategy are the dominant parts of the current leading FMT system. In conclusion, understanding from the view of holistic integrative medicine is the basic step to practice FMT and move it into medicine mainstream.