Case reports are a valuable resource in the era of genomic testing

The paper by Zafeiriou et al. (1) describes exceptionally prolonged remission ranging from 3 to 15 years observed in three cases with homologous DNA repair mutations in metastatic castrate resistant prostate cancer (CRPC). The exceptional response has always been the most intriguing part of the clinical practice of medicine. Every physician sees at least one unexpected/exceptional responder during their medical practice careers.